Lung Diseases

Cell therapy as part of a comprehensive lung function restoration program

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Common Indications

Patients most frequently seeking cell therapy programs present with chronic or residual lung damage accompanied by inflammation, impaired respiratory function, and reduced tissue repair capacity.

The most common conditions include:

  • chronic obstructive pulmonary disease (COPD)

  • pulmonary emphysema

  • pulmonary fibrosis and fibrotic changes of lung tissue

  • chronic inflammatory airway diseases

  • recovery after severe pneumonia and viral lung injuries

In these cases, cell therapy may be used as part of a comprehensive treatment approach to support regeneration and improve the patient’s quality of life.


Which stem cells should be chosen?

In regenerative therapy programs for lung conditions, the most commonly used cell types include:

Donor-derived mesenchymal stromal cells (MSCs) from the umbilical cord or placenta
These cells exhibit strong anti-inflammatory and immunomodulatory effects, help improve microcirculation, and support regenerative processes within lung tissue.

Umbilical cord blood stem cells
These may be used as an adjunct component of therapy to promote regeneration and maintain immune balance.

The cell type, route of administration, and dosage are individually determined following a comprehensive medical assessment of the patient’s condition.

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Impact of therapy

Cell therapy does not replace standard treatment for lung diseases but may serve as an important complementary component.

Potential outcomes include:

  • reduction of chronic inflammation

  • improved tolerance to physical activity

  • support of tissue regeneration

  • stabilization of lung function

  • improvement of overall well-being

  • mitigation of the effects of systemic inflammatory response (“cytokine storm”)

  • reduction of pulmonary fibrosis


Your treatment plan in QR Health Solutions:

Day 1 Examination

Consultation and diagnostics include physician evaluation, laboratory and instrumental examinations, and the development of an individualized treatment protocol.

Day 2 Preparation

Preparation for cell therapy includes preparatory infusion therapies and supportive medical procedures.

Day 3 Therapy

Administration of the cell-based therapy includes a pre-procedure patient assessment, medical supervision during the procedure, and clinical monitoring for several hours afterward.

Day 4 Follow-Up Evaluation

Follow-up care and monitoring plan include assessment of the patient’s overall condition, provision of recovery and lifestyle recommendations, development of an individualized follow-up plan, implementation of remote medical monitoring, and scheduling of the next visit as needed.


Sources:

World Health Orgnizaion. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: interim guidance, 13 March 2020. World Health Organization, 2020. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet Wilson JG, Liu KD, Zhuo NJ, Caballero L, McMillan M, Fang XH, et al. (2015). Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respiratory Medicine, 3:24-32. Hashmi S, Ahmed M, Murad MH, Litzow MR, Adams RH, Ball LM, et al. (2016). Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis. Lancet Haematology, 3:E45-E52. Kamen DL, Nietert PJ, Wang H, Duke T, Cloud C, Robinson A, et al. (2018). CT-04 Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cells (MSCs) in patients with systemic lupus erythematosus: results of an open-label phase I study. Lupus Science & Medicine, 5: A46-A47. Li W, Ren G, Huang Y, Su J, Han Y, Li J, et al. (2012). Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ, 19:1505-1513. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia inWuhan, China. JAMA. Leng Zikuan, Zhu Rongjia, Hou Wei, et al. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Aging and disease, 2020, 11(2): 216-228.

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